Dr. Asim Abdel-Mageed
Zimmermann Endowed Professor
- New Orleans LA UNITED STATES
- School of Medicine 3548
- Urology, Pharmacology & Tulane Cancer Center
Dr. Abdel-Mageed's lab focuses on the cellular, molecular & translational aspects of urologic diseases, especially prostate cancer
Biography
Areas of Expertise
Education
Kansas State University
Ph.D.
Molecular Physiology/Toxicology
Kansas State University
M.S.
Molecular Physiology/Toxicology
University of Khartoum
D.V.M.
Links
Research Grants
Targeting Tumor-derived Exrna-containing Microvesicles by High Throughput Screening
NIH
Dr. Abdel-Mageed's laboratory has discovered a novel role for tumor-derived exosomes in neoplastic reprogramming of mesenchymal stem cells, thereby potentiating clonal expansion of tumor cells at their primary and metastatic sites. This new concept attracted funding ($4.2 million) from the NIH/National Center for Advancing Translational Sciences (NCATS). The objective is to target tumor-derived exRNA-containing microvesicles by high throughput screening of ~ 4,000 human approved drugs. The ultimate goals is to reposition FDA approved drug(s) to inhibit biogenesis/release of exosomes by tumor cells and/or their uptake by recipient cells to reduce or circumvent tumor growth in cancer patients.
Articles
Neoplastic reprogramming of patient-derived adipose stem cells by prostate cancer cell-associated exosomes
Stem CellsZakaria Y. Abd Elmageed, Yijun Yang, Raju Thomas, Manish Ranjan, Debasis Mondal, Krzysztof Moroz, Zhide Fang, Bashir M. Rezk, Krishnarao Moparty, Suresh C. Sikka, Oliver Sartor, and Asim B. Abdel-Mageed
2014
Emerging evidence suggests that mesenchymal stem cells (MSCs) are often recruited to tumor sites but their functional significance in tumor growth and disease progression remains elusive. Herein we report that prostate cancer (PC) cell microenvironment subverts PC patient adipose-derived stem cells (pASCs) to undergo neoplastic transformation.
High circulating estrogens and selective expression of ERβ in prostate tumors of African Americans: Implications for racial disparity of prostate cancer
CarcinogenesisZakaria Y. Abd Elmageed, Krzysztof Moroz, Sudesh K. Srivastav, Zhide Fang, Byron E. Crawford, Krishnarao Moparty, Raju Thomas, and Asim B. Abdel-Mageed
2013
Although estrogen receptor beta (ERβ) has been implicated in prostate cancer (PCa) progression, its potential role in health disparity of PCa remains elusive. The objective of this study was to examine serum estrogens and prostate tumor ERβ expression and examine their correlation with clinical and pathological parameters in African American (AA) versus Caucasian American (CA) men.
PDZK1 is a novel factor in breast cancer that is indirectly regulated by estrogen through IGF-1R and promotes estrogen-mediated growth
Molecular MedicineHogyoung Kim, Zakaria Y. Abd Elmageed, Jihang Ju, Amarjit S. Naura, Asim B. Abdel-Mageed, Shibu Varughese, Dennis Paul, Suresh Alahari, Andrew Catling; Jong G. Kim; and A. Hamid Boulares
2013
Although a relationship between PDZK1 expression and estrogen receptor (ER)-α stimulation has been suggested, the nature of such a connection and the function of PDZK1 in breast cancer remain unknown. Human tissue microarrays (cancer tissue: 262 cores; normal tissue: 87 cores) and breast cancer cell lines were used to conduct the study. We show that PDZK1 protein expression is tightly correlated with human breast malignancy, is negatively correlated with age and had no significant correlation with ER-α expression levels.
Synergistic inhibition of thyroid cancer by suppressing MAPK/PI3K/AKT pathways
Journal of Medical and Surgical ResearchEmad Kandi, Koji Tsumagari, Jingjing Ma, Zakaria Abd Elmageed, Xinying Li, Douglas Slakey, Debasis Mondal, Asim B Abdel-Mageed
2013
Although a wide spectrum of inhibitors of the MEK/ERK and PI3K/AKT pathways have been discovered and entered clinical trials, the effects of their individual use in thyroid cancer were often disappointing. We hypothesized that dual targeting of these two pathways would be a safe and effective strategy against aggressive thyroid cancers.
Adipose tissue derived stem cell-seeded small intestinal submucosa for tunica albuginea grafting and reconstruction
Proceedings of the National Academy of Sciences of the United States of AmericaLimin Ma, Yijun Yang, Suresh C. Sikka, Philip J. Kadowitz, Louis J. Ignarro, Asim B. Abdel-Mageed, and Wayne J.G. Hellstrom
2012
Porcine small intestinal submucosa (SIS) has been widely used in tunica albuginea (TA) reconstructive surgery. Adipose tissue-derived stem cells (ADSCs) can repair damaged tissue, augment cellular differentiation, and stimulate release of multiple growth factors. The aim of this rat study was to assess the feasibility of seeding ADSCs onto SIS grafts for TA reconstruction.